Identification of distinct loci for de novo DNA methylation by DNMT3A and DNMT3B during mammalian development

(The Institute of Medical Science, The University of Tokyo) A research team working at The University of Tokyo and Kyoto University in Japan has announced that they have successfully identified specific target sites for the DNA methylases DNMT3A and DNMT3B . The researchers also found that DNMT3A specifically regulates differentiation-related genes and DNMT3B specifically regulates X-chromosomal genes during mammalian ontogeny.These results were published in Nature Communications (online version...